Unless your every position has high substats even with Edo Itachi you can get oneshot with 20k+ crit/injury Hiruzen and other ninjas. Defensive lineups need every position to resemble "stacked move 1", I used Chiriku+EM+Hokage Minato today in ST versus a player with 16k substats Angel Konan (my move 1 is 20k substats). Even with all the defensive ninjas it still came out to Konan vs Minato (my p2-p4 9-7k) in the end, although they survived 1st Konan mystery.