Hi! Are you looking for highest power or most optimal Chakra runes to run for your lineup? In my opinion, some of the great runes that work for many lineups would be Initiative, Ninjutsu, Taijutsu, Defense, Resistance, Damage Reduction, Life, and Critical. Some other stats can help with more specific builds would be control, injury, Taijutsu and Ninjutsu Pen3tration.

However, this is kinda subjective based on what lineup you use and what you are looking to do. If you want though, posting your lineup and an explanation of what you can do can help us help you better xD

~Jib