it's pretty hard to test it because late players have high enough of the 3 stats to actually not see any differences and cannot remove them because they come from passive effects like Myoboku Balance cultivation or Summon cultivation or Group skills.

This is the example of my move 1:

i'm one of those damage reduction overstackers, so you won't see many people with a ton more damage reduction than me and still, even if i never deliberately went for p3netrations, i own them high enough to basically overcome any commonly stacked enemy damage reduction (your usual 130-140k player owns 2000-2200 damage reduction).

If i add two inner gates runes with lets say 800 nin and tai p3netration, unless i meet somebody like me, that 800 p3netration do not give me any effect if what people like Scarlettblue and Xkorpitron said is true, overall because we do not know how actually damage reduction interacts with defense and resistance. Could be, as far as we know, that the 200 damage reduction i would overcome on the common 2200 damage reduction player by adding those runes is actually a quantity of damage lower than the RNG aleatority effect.