First time I got my Hashirama was never.

But, I've gotten 3 other ninja from boxes before

Sasori-Opened him up in a lone box, don't know how much I opened prior to him

Tendo-Opened him in a set of 55, 55/85 of my boxes up to that point

Tobirama Senju-First ten back in August.

I've still yet to get Hashirama, even after 50, it's all luck.