I normally go like this...
x Kabuto x
Sakura - Sage Naruto - Kidomaru
x x x
And move the entire row up or down depending on your opponents. Before when I was Fire Main, I normally just swap in the Main into that Sage Naruto slot. This team has little burst, but strong enough to wipe out your opponents, while lots of heal in place, I don't think its the best, but it kinda works.
So I normally don't even use my Main at all through all 12 checkpoints and 5 breakthroughs. This 4 last me all the way. But you can try the Chinese Combo simulator, to test out the main and his talents to fit into that slot. Kakashi is replaceble for Sage Naruto, and Kimimaro is replaceble for Kidomaru.