1st Round Let the earth main get his interrupt on your water main first then you c*e AO mystery on Hashirama make sure your water clone dies as well.
2nd Round Sakura heal into Mei mystery onto Jiraiya right away Sakura with her slugs should end up killing jiraiya and hashirama
3rd round Try to mystery heal with your main as fast as possible to get rid of earth main's interrupt as well as take away the chakra so Tobirama does not use his mystery.
4th Use Ao and mei mystery on tobirama which should kill him
5th round is basically cleanup with poison and your basic attacks with mei and water main (Ao should have died by now)