I find that this is the most balanced offense and defense wise. If you put in Karin instead of Shizune you'll get even MORE poison and damage but less healing.
The reason why I put the Main up front is because a lot of people tend to put Hinata in Move 1 in a LOT of builds. I've mentioned in a lot of Guides before, Move 2 Ninjas can NEVER EVER beat a Move 1 Ninja. Not in a million years unless it's a very special event. By having Hinata in Move 1, you're losing in terms of speed so having the Main in Move 1, you can beat most other players that have Hinata there.
Once you reach level 55, you can start to explore a little more, but until then, this is the most annoying i've ever seen because the sheer number of disabling debuffs prevents the damage debuffs from getting through.