If you wanna * with Empress, which is talents 2,3,x,1,2, I'd recommend getting Ninja Monkey or White Tiger, in order to keep the combo complete. The issue with using Sakura over another healer (Karin in particular), is that Sakura's heal doesn't cleanse, which means that the Main, the best source of damage, can be easily shut down by Acu and thus can be beaten easily. If you wanna use Shizune to compensate for that, you c*e talents 2,3,1,1,2 with White Tiger. Shizune is more defensive than Karin, as her attack is her heal, but can clear two debuffs at once and deal more damage to poisoned enemies with her chase.
Hope this helps a bit! :victory:
Kfactor5953