If you wanna * with Empress, which is talents 2,3,x,1,2, I'd recommend getting Ninja Monkey or White Tiger, in order to keep the combo complete. The issue with using Sakura over another healer (Karin in particular), is that Sakura's heal doesn't cleanse, which means that the Main, the best source of damage, can be easily shut down by Acu and thus can be beaten easily. If you wanna use Shizune to compensate for that, you c*e talents 2,3,1,1,2 with White Tiger. Shizune is more defensive than Karin, as her attack is her heal, but can clear two debuffs at once and deal more damage to poisoned enemies with her chase.
Hope this helps a bit! :victory:

Kfactor5953

So I should replace sakura with shizune and then when I get Karin, replace shizune with her?

i prefer not to use all female formation , since this formation only good for 3 early round , if you can deal heavy damage with your main in the 1st 2 Odama Rasengan then use it , if not just * with Wind member formation

ok thanks

So just recently got anko to, is she any good?

Meh, not really? She buffs fire ninja so if you're using Kurenai then it might help a little, but overall I'd avoid using her unless you're a Fire Main.

Ok thanks