The Mystery has a 3 turn CD and if you really want to use it as a Interrupt you need to attack turn 1-2 or in most cases vs good players it will be useless.
Sleep attack is strong but he can't start combo's with it like the other mains, all you need is a clone or puppet as a shield. (should have that anyway you really need a shield on your front row ninja for turn one-two.)
The mirrior is a very strong talent reflect and more importantly increased damage to targets with ignite, that's why Tobi deals so much damage with fire mains.
Bani Chakra *s and never get's used as far as I can tell. we need a clone shield after all.
Death Mirage would be a great talent but it always will target your main and one random ninja next to him. It will not pick debuffed targets from what I have seen and a clone shield is better anyway.
If you pick all the debuffs and what not fire mains don't deal that much damage.
Now earth mains my lvl make two 2k+ shields every turn and another 2k+ every time they use their mystery.
Lightning mains can become immune to debuffs (very underrated talent it' s very strong.) high single target damage can attack lowest HP ninja and has a high chance of starting combo's. They also have an Acupuncture that's better than the fire main interrupt in most cases, leach to their whole team and if you have not seen a lightning main destroy a whole team in ranked after Tendo attacks than you are lucky.
Water is by far the best support / healer in the game. People just need good ninja to go with her.
Wind is not bad but again needs good ninja to go with her, Just wait till the better Garra/Temari are released. The main weak point of wind mains that I have seen is that they never take ninja with debuffs, they go for pure damage but don't have ninja for it yet.