Shisui is like a threat to me. Founder Madara is tough when paired up with either Anbu Itachi or Shisui. But mostly Water main in 1st position or Kurenai with that reflection passive and debuff removal is annoying when you don't have enough initiative or when your debuffs can't hit the opponent. It is even worse when they pair up together and either way you have a ninja with a reflection passive or immunity to debuffs because either way, it stops your mystery