I used neji/sasuke/kabuto. Its not the only combo, but it worked, so i wasnt looking for something else. I think its also possibly to use sai or similar chars.

Crucial moments:
-We need 2 combos
-We need interruption

If you wanna clear it solo then rotation is quite simple. Use neji interruption on top giant (most likely mid one ll get acupuncture from main). Use interruption on shizune, wait her heal, use first combo and next round another combo. At karin wait her poison and heal, start combo, interrupt poison, start second combo. And final with hanzo is easy. This post was last edited by MarryDarry at 2016-9-14 16:01

i used main ( full heal)-sasuke-neji
sai -x-x take deer as summon
and talents water style shark bomb and water clones jutsu with this build u can even solo hard mode:P

I used

Azure Fist (Healing)-Sai-GNW Neji
*x-Kakashi-*x
*x-*x-*x

Though this was in collaboration with another person using Sai with a decent combo team, also all members of the team saving their moves for the right moment is important. If you go in with 2 people in the team, I recommend interrupting two of the giants in round one, then for round two wait until Shizune has 8-6ish health because of Sai/Kabuto's clones and then all-out combo her down, then finally focus Karin and interrupt Hanzo as much as you can until Karin is dead then focus Hanzo.

Good luck.~

you can solo with this build quite easily

and the talents were

heres what you do
WAVE1
just interrupt the giants when you see fit the middle giant will be dealt by your team so dont focus but rather work on the top or bottom giant
make sure to have a neji skill saved for wave 2
WAVE2
you have 2 skills use one after shizune heals and the second skill in the next round (you will know the round is over when you take poison damage)
Wave3
this is the toughest cause your timing has to be perfect karin can heal twice a turn once before attacking normally and once before using her skill if you interrupt the skill she wont heal twice(she will only heal once)
what you need to do is use one attacking skill after her normal attack but make sure your neji skill has either 1 round remaining or is already ready
as soon as the next round starts use neji skill and the second attacking skill and you won
Wave4
hanzo is very easy just make sure to interrupt his skill when you see it and your good

use shurado if you have one, and if you are lvl 65+ dont waste your runs and do the difficult one, it gives more rewards than the easy and normal mode.