He did have immune to all debuff and he is immune to ninjutsu which counter 6p naruto's standard attack and chase(pure ninjutsu dmg).

This mean that naruto cant leech hp with standard attack and chase.

Not to mention that naruto mastery deal both tai and nin dmg, since madara able to negate nin jutsu dmg.

He will take less dmg from 6p naruto mastery (Quote me if im wrong)

One thing I liked about his kit is certain hit(unavoidable) standard atk and high chance knockdown then proceed to chase.