general idea is you want to use as many multi target mysteries round 1-2 as possible. against ninjas such as naruto, edo hashirama and edo minato it is hard to achieve. if you want to go with han, you shouldn't bring many ninjas with removable buff such as iruka.

one underrated ninja to keep in mind is torune, if your fight doesn't end quickly that poison will do a lot of work (assuming he doesn't get interrupted by kisame/madara 5 kage)

good luck