initiative(it's for 20k points in the point shop), crit, injury, attack, ninjutsu, resistance, and defense. Once you unlock the death rune at lvl 100 put life there. Don't listen to the people that'll argue over tai/nin p3n3tration's worth, people in this version have tested it many times before the forum update thing, and people playing in cn have tested it and got the same result that it effects nothing(they've tested using high gains of *ion). If that doesn't convince you, cn's official testing grounds, orochimaru's lab have tested it a couple time and they didn't get any evidence of p3n3tration working.

-_- dude, have you even read nin/tai p3n3tration's effect. Even if what you said was true, orochimaru's lab(it's the official testing done by tencent) would know that and test inin/tai p3n3tration also on it.

nevermind you were correct, tencent reviewed their test 5 days ago, nin/tai *ion doesn't show any effect on kakashi clones because they don't have defense/resistance. https://www.youtube.com/watch?v=pZ2m0j9pnuQ based of this, the best runes would be crit, initiative, injury, tai *ion, attack *ion, attack, ninjutsu, and when you unlock death gate you should get dmg reduction/life/resistance/defense but i'd do some personal testing to see how much damage p3n3tration actually does before opting to use it.