In my opinion:

Wind
+Resistance -Def
+Ninjutsu -Def
She is the only one in Standard Empress that can activate a combo with her mystery, so if your magatama & refine is low, perhaps -ATK is more viable.
She is also a massive target to anyone who knows how to fight most Empress teams, so it's smart to not reduce her DEF depending on your situation.

Kurenai
+Resistance, -HP if she is 4*+
or +Resist -Atk is very good in general, though I do like having Empress dealing more damage -- this depends on magatama, star level, and refines.
High priority target for some people, but most will go after your main if they know how Empress works.

Hinata
+HP, -Nin
You could also very well go for -ATK if you're unlucky in getting -NIN, but try to get -NIN. She will often get targetted in an attempt to break your control, but if she doesn't die fast enough, the other team's probably going to get in pretty bad shape.

Karin
+HP, -ATK
She is not a very strong healer, but her poison is quite good, so it's up to you which weighs more if you want to reduce/increase her Ninjutsu instead -- her stats are already increased by Queen and Flower Guard anyways.
This post was last edited by Amadeu at 2016-10-9 09:49 This post was last edited by Amadeu at 2016-10-9 09:53