Atm edo hashirama is really squishy, so you need to target him. Once he dies, go for the main. Also worth a note is that if you can put someone with Han's passive (resistance to autos) in front of naruto, he won't be able to reset his mystery.

If you have init advantage, running the cheaper kurama - sharkisame - edo tobirama - earth main, would net a win pretty easily.