I will give u example from my team:

Position1: Jonin Minato, 2: Masked Man, 3: Wind Main, 4: Kurenai

versus my friend test dummy for this

Position1: Roshi, 2:Masked man, 3:Water Main, 4:Sakura Sailor

ROUND 1 i use masked on roshi(usless move just testing)

Round2 : Sailor and water main use heal, I use minato who is fastest ninja on water main(interupt her and control on combo)

now SITUATION1 i use wind mastery reset while minato is attacking, and it sucess before sailor heal. while that is happening i am clicking on keyboard and with mouse like crazy masked man skill on sailor and he ALWAYS fail to use skill,he delay it after sakuras heal or even normal attacks...

now

SITUATION 2 all same only in moment when Wind main use mastery i click on AUTO skills, Masked in instant afer that activate his skill on sakura...

How on auto works great and on normal i always have deley..... :/