My guess is its something like the top 8 in a group will be randomly matched against the bottom 8. As someone who's in the upper half of a group for spacetime every season except the first, I can vouch that my first opponent has always been 9 or lower. After the first round I haven't paid enough attention to things to see if something similar is going on, i.e. if matches go according to seeding with no upsets then round 2 will be top 4 in a group versus 5-8 in some random matching, and so on.
Thus your motivation is to at least get enough points to crack top 8 in a group (which I guess would be top 64 overall) so that you can have an easier opponent in round 1.
Also this is still all guesswork so take it with a grain of salt, though the evidence does support it to some degree as I look over first round pairings in my spacetime.
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