When the 3 sannin war had join forces. they were had an good teamwork jiraiya,orochimaru,tsunade.
Hanzo was there opponent. Hanzo throw a explosive tag to tsunade.
he didn't succeed. jiraiya use the jutsu
Ninpou; Hari Jizou!

and orochimaru attack hanzo with his snake jutsu.
but they didn't succeed. hanzo had escaped on that deadly jutsu used by orochimaru
nagato uzumaki died by his comrade
the one who killed him was tendo.
If I were there. ill use the izanagi to nagato.