I was using 3 star Hashirama, 8 Gates Lee, Iruka and Earth Main but i find 5 star Yamato does a lot more overall damage then Hashirama. Even with Iruka losing the 40% from Hashi barrier Yamato more then makes up the difference. Yamato's passive attack does around 40% more damage then Hashi's and even if Yamato doesn't crit on his standard he does almost as much as Hashirama's standard crits.

Swapping Asuma Windblade for Iruka was an overall loss of damage from what I saw.