Only Mei does more damage to males, not your team deals more damage to males or all males take more damage.
As for a team, the most common Fire Main Mei team I see is
Mei - S.Naruto - x
FM - Ao - x
x - x - x
Talents: 44321 with Gamaken or 44421 with Dog of hell
For myself, I use
S.Sakura - x - x
x - x - x
Hanzo - Mei - FM
Talents: 24321 with Monkey King
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