Depends on the situation....say for example Pain shurado is a good dps with combo skill that can trigger lots of hit each round...he is a dmg ninja...you can build with guy, lightning main, asuma (wind blade)...and then later on...nagato (edo tensei ) this one..mainly used by wind main with S.Naruto, kk.Gaara. He is a AOE ninja with his mystery that can eliminate all the buff in first round...you should consider to put him in last line since his mystery is not promp....and then gakkido...he is a debuff ninja...mainly used by wind main with S.naruto, kk.gaara, removing one layer of debuff every round is one of his useful skill..he is also good at rank battle team. The last one jigokudo....he is a healer with chasing ability...and also the passive of rinnegen give him a certain amount of defense for 3 round...a very powerful ninja...you c*e him in immortal team lineup or some healer team deal poison and ignition debuff to your opponent like mei, hanzo, water main...