I usually just use blitz to kill roshi ASAP. I use LM darui mifune and guy. Hope that helps :)

Blitz (unreliable sometimes but works as long as Roshi dies and Hidan keeps dying before killing you)

Water Main skewering mystery - (target Hidan r2, make sure he is immobilized), I've won against this team when the opponent had somewhat higher power thanks to being able to shut down Hidan and survive

Wind Main Sand Dust - remove root, control Hidan (maybe even chaos him, haha)

Other Buff clears - Mifune, in the future...Han

r1 Debuff Clears - Normal Sakura, Gakido, Hanzo, 5th Hokage Tsunade, Fire Main 4th Mystery

"Cannot revive when killed by this" - Mabui (time it just right), Third Hokage (maybe even a team that takes advantage of being able to use Death Seal repeatedly)

I'd say NO to skewering for Water Main. That mystery is very situational.
Before you can even use it you're probably half dead before round 2 even starts.
I'd rather use heal or shark instead.
To make skewering efficient that Water Main has to take front line to make best initiative before Roshi takes you down with ignite.

Spam healing has the least chance to win u won't heal fast enough against that team if he focus only single target with aoe.