Since you are a relatively new player let me tell you a thing. With low level refinement runes you could even behave that way without losing much up to last month but with medium/advanced ones no. What you want is to use them in big stacks (100+) only when the time limited refine event is up.
But now that we got also the refine rebate what you want, if you are close to it, is to use all your low level refinement runes in that event because that grant you advanced refinement runes for free. Right now you won't feel the difference because you aren't in the rank5+ inferno, but later you'll regret it if you don't do so. (You could think to rank them up without caring about this only if by level up your refinement rank on an item you are sure to get 1st or 2nd place in your intraserver sage world battlefield, otherwise don't even think to do it outside rebates)