Hashirama with the buff and immobility and interrupt with Iruka and Sage Naruto with Earth main would be ideal for a lot of damage.
Hiruzen would also be great for space time battles when you've gotta take someone such as the main character down which can be a great game changer.
Tobirama is great with water main for damage but he will be targeted mostly because of his mystery, beside his mystery Tobirama isn't all that great imo.
Minato is great for the front lines, his tag comes in handy with other ninjas like say Hidan or Ay and his passives are nice.


For me, I'd go for hashirama, Iruka, SN and earth main for the maximum damage and you can replace other passive barriers with hashirama. You could also use fire main with hashirama for round 1 debuff immunity so you can successfully use hashirama's barrier.