Opinion of someone who uses 6tails immortals team -
It's not easy to counter without having the ninjas required. Obivous Danzo and Sn Itachi stand out to chaos both tsunade and sakura then go to town on the tank but that's basically what you have to do to shut down the healing/debuff removal.
Ignite/Immobile are both needed in lieu of Chaos, and it needs to be layed down until tank is dead otherwise they recover. You may as well retreat the battle if your barrier fades and someone isn't going to die that round before a heal hits.
Hashirama is a great dice roll against the team, but he can still be rendered useless after the initial push by a Tsunade mystery.