I don't think so. Poison can be healed through, it's not like ignition. I actually use a vampire team for Hanzo and that place spams poison for days that you can't cleanse on the hardest difficulties.
Shizune and Karin means you're using two healers as your offense which Midnight Blade can annihilate with his combo, which ends in ignition from Guy so it reduces your healing. There's not much threat in the meantime coming from healers and Sakura can clear high poison stacks.
Kankuro and Chiyo meanwhile just use puppets. Midnight Blade eats puppets for breakfast with bloodthirsty. This team is also extremely Taijutsu based which is the weakness of any puppet team, relentless damage buffed offense. Even if Kankuro and his clone were behind a tank I just walk right past that tank.
I meant one healer with poison and one puppet with poison.