She sounds good, definitely worth trying. Sorry, I dont have mei, but maybe she will be better than anko.
1) Her barrier is passive, so Unlike anko-she will do standard attacks on all 4 rounds (compared to anko who only does in 2 rounds), attacks are elemental too, so more overall dmg.
2) 25% Buff to male ninja - this is very useful for main and iruka. Should be the main difference here..
3) you should use mei on 4th round, not sure how much dmg it will do though. But should be good and its elemental too.
Cons - 1) Mei don't get shield from iruka. So if kyubi does AoE attack, she will take dmg and asuma's buff will be gone.
2) Her barrier lasts for 3 round. So on 4th round your dmg will drop a little.
Try it with mei and post here how it goes, I'm interested about this too.